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efocipegtrutide ( LAPS Triple agonist) efpegerglucagon ( LAPS Glucagon analog) HM97662 (EZH1/2 inhibitor) BH3120 (PD-L1/4-1BB BsAb) HM15275 (LA-GLP/GIP/GCG) HM16390 ( LAPS IL-2 analog) HM17321 (LA-UCN2) HM101207 (SOS1 inhibitor) LAPS Glucagon Combo HM15275 (LA-GLP/GIP/GCG) Overview As a long-acting glucagon-like peptide (GLP-1), gastric inhibitory peptide (GIP) and glucagon triple agonist, HM15275 achieves more favorable pharmacodynamics profile in addition to once-weekly dosing

Acta Neuropathologica 125 , 359371 (2013)

In a trial by Iepsen et al., 37 women with an average age of 46 (Standard Deviation: 2 years, range 18-65 years) and BMI of 34 (SD: 0.5 kg/m 2 ) achieved a 12% weight loss after 8 weeks of low-calorie diet modifications

Todays choice is between current oral semaglutide with its strict timing requirements and once-weekly injections that offer different flexibility